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It was determined that active structures required ortho, meta, or both positions to be fluoromethylated, inactivation occurred if the para position was so filled (as if full activation needed access to the meta site for hydroxylation), the molecule needed a benzoyl structure, and the response may be mediated by
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HEALTH EFFECTS - Toxicological Profile for DEET (N,N-DIETHYL-META

https://www.ncbi.nlm.nih.gov/books/NBK592096/?report=reader
HEALTH EFFECTS - Toxicological Profile for DEET (N,N-DIETHYL-META-TOLUAMIDE) - NCBI Bookshelf Your browser does not support the NLM PubReader view

Entrez Direct: E-utilities on the Unix Command Line - EntrezĀ®

https://www.ncbi.nlm.nih.gov/books/n/helpeutils/chapter6/
Entrez Direct: E-utilities on the Unix Command Line - EntrezĀ® Programming Utilities Help - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function