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And in a way it's too bad, because stereoelectronically there's nothing quite like a nitro group, and if it weren't for such difficulties I'm sure we drug researchers would have found many more uses for the things
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Can't Stop the Nitro Groups | Science | AAAS .grouped.download-toggle

https://www.science.org/content/blog-post/can-t-stop-nitro-groups
And in a way it's too bad, because stereoelectronically there's nothing quite like a nitro group, and if it weren't for such difficulties I'm sure we drug researchers would have found many more uses for the things