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This “bouncing conga line of nucleotides” actually forms knots that—if left uncorrected—would result in improper RNA function and possibly diseases
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Human High-Altitude Habitation Reveals Adaptive Design | The Institute

https://www.icr.org/article/human-high-altitude-habitation-adaptive-design/
Previous studies have shown a propensity for a few different gene variants to exist at higher frequencies in high-altitude populations, but nothing definitive has been found as to a significant and consistent heritable genetic mechanism that would explain the unique changes in physiology and anatomy