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The results showed that, similar to HIF-1α, TRIM28 and all three subunits of DNA-PK were recruited to the HREs of two prototypical HIF target genes, ANGPTL4 (HRE is located in the 5′-flanking region, 2012 base pairs upstream of the transcription start site)24 and PDK1 (HRE is located in the first intron, 760 base
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HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase

https://www.nature.com/articles/s41467-021-27944-8
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Promoter-proximal RNA polymerase II termination regulates transcription

https://www.nature.com/articles/s41594-025-01486-9
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TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause

https://www.nature.com/articles/nsmb.2878
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https://www.nature.com/nature-index/file/2021-Nature-Index-Brochure
*¥9ÈÛbÙ* ÓFöå I_›R˜¾5¿ÚW[F¼ºéÈM^`Gå̧^ Žã‘Z[uÈåiPhL’V2NA¯Wgl[šV-‰´ª†%Rº¤ÒZ“°6Ìíš ‚¡q'·:“š›6£GuqížP°µõ²×§\î0¢;m�gv3êD—ÛiÂÒD悜H^öè´|Ebìuš´–|4XíBÚVÒwð×pùK4÷Ìó ‹2]‘EgA*MÚ&•Å7&ïŽ;Hi};´KÖÓäÜ}›Ï}‰ I»\ ¡¨ÆÓÒ”± kM€·V⸌䜚ïfå=™bY œ“ªáâ³&Ç ¥ QZ«·dUûTÙ%£OimMªô}’mƒRi(‘äXïOººãjëÆƒè*—-æù€BÒPB‡‘ƒU,+:ž+"

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https://www.nature.com/articles/s41586-026-10969-8
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