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The results showed that, similar to HIF-1α, TRIM28 and all three subunits of DNA-PK were recruited to the HREs of two prototypical HIF target genes, ANGPTL4 (HRE is located in the 5′-flanking region, 2012 base pairs upstream of the transcription start site)24 and PDK1 (HRE is located in the first intron, 760 base
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https://www.nature.com/articles/s41467-021-27944-8
HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia | Nature Communications
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https://www.nature.com/articles/s41594-025-01486-9
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https://www.nature.com/articles/s41586-026-10969-8
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https://www.nature.com/articles/nsmb.2878
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