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3d validates reduces nirsevimab neutralization in another subtype A strain); we speculate that neutralization of strain PP_001Y2UB might be affected by an epistatic interaction between S211R and a second R213S mutation it contains at a nearby site
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https://www.nature.com/articles/s41586-026-11030-4
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https://www.nature.com/articles/s43588-026-01042-5
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https://www.nature.com/articles/s41586-026-11044-y
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https://www.nature.com/articles/s41586-026-11012-6
However, previous attempts had considerable limitations: fixed tree topology, simplified evolution models, inability to handle missing data, no site rate heterogeneity and the absence of an ancestry prior34,35,36,37,38,39,40,41,42
https://www.nature.com/articles/s41586-026-10980-z
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https://www.nature.com/articles/s41586-026-10787-y
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https://www.nature.com/nature-index/news/open-framework-tackles-backwards-science
She created a public project called The Grackle Project on the OSF, but most of its content- including project files and a wiki that documents lab standard operating procedures - is accessible only to her collaborators, a decision she made in order to ensure that data files cannot be edited by outside parties
https://www.nature.com/articles/s41586-026-10988-5
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https://www.nature.com/articles/s41467-024-48916-8
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https://www.nature.com/articles/s41564-024-01635-8
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https://www.nature.com/articles/s41586-026-10950-5
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https://www.nature.com/articles/s41586-026-11024-2
This method enables RNA-programmable site-specific integration of single or double-stranded DNA fragments
https://www.nature.com/articles/s41586-026-10926-5
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https://www.nature.com/articles/s44271-026-00415-w
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https://www.nature.com/articles/s41597-022-01163-2
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https://www.nature.com/articles/s41597-026-06884-2
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https://www.nature.com/articles/s41380-026-03880-1
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https://www.nature.com/articles/s41586-026-11035-z
Middle, sequencing performed for each patient, with the number, site and histology of tumours in each patient
https://www.nature.com/articles/s41586-026-10979-6
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https://www.nature.com/articles/s41467-024-49211-2
We also profiled cell frequencies by fluorescence-activated cell sorting (FACS), biochemical profiling, differential gene/peak expression, enriched biological pathways, over-represented transcription factor binding site (TFBS), antibody isotype, mutation profiles of BCR/TCR, cell-free RNA (cfRNA) in plasma, and
https://www.nature.com/articles/s41467-024-49212-1
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https://www.nature.com/articles/s41586-026-10922-9
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