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However, this glycosylation site is not formed in natural sequences due to no S/T residues at site 101
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However, previous attempts had considerable limitations: fixed tree topology, simplified evolution models, inability to handle missing data, no site rate heterogeneity and the absence of an ancestry prior34,35,36,37,38,39,40,41,42

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https://www.nature.com/articles/s43588-026-01042-5
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https://www.nature.com/articles/s41597-022-01163-2
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