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At 24 h after these constructs were transfected together with miR-138 mimic into HEK-293T cells, the activity of the luciferase fused with FBLN5-wt targeting sequence was significantly reduced, whereas the FBLN5-mut was unaffected (Figure 2C), implying that this site on the 3’-UTR of FBLN5 mRNA was directly targeted
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https://www.aging-us.com/article/202465/text
microRNA-138 relieves pelvic organ prolapse through the FBLN5/IL-1β/elastin pathway
Bing Zhao1Department of Gynaecology and Obstetrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China, Qing Sun1Department of Gynaecology and Obstetrics, The Third Affiliated Hospital of